Services

AI-based Analysis

Organ segmentation is essential but tough and prone to errors if done by hand.

We introduced a lightning-fast deep learning solution that segments major organs, cells, lymph nodes and bloodvessels! Achieves speeds orders of magnitude faster than other algorithms.

Matches or even tops the quality of top-tier approaches and human experts.

Directly aids biomedical research, e.g. by pinpointing cancer metastases!

Tissue Clearing

Discover the power of optical tissue transparency for 3D exploration of complex tissues!

Adult rodent, porcine, mokey or human organs, dense from years of life, now made transparent!

Moreover, we can scan and analyse fluorescent markers based on Cre reporter strains!

Our groundbreaking method to clear and label tough human organs, like connective tissue, bones. Dive into the human eye, thyroid, kidney, skull, etc. all at cellular detail!

Biodistribution Assessment

A groundbreaking pipeline for automatic quantification of cancer metastases and therapeutic antibody targeting!

Enhancing the fluorescent signal of single cancer cells or CAR-T cells by over 100-fold using vDISCO method in transparent mice. Tested in 5 metastatic cancer models: including breast, lung, and pancreatic cancers.

Detailed analysis: metastasis size, shape, distribution, and antibody targeting effectiveness in whole mice.

DeepMACT can turbocharge the discovery of powerful antibody-based cancer treatments in pre-clinical stages.

Biopsy / Organ Analysis

Explore the world of spatial molecular profiling in complex tissues!

Our groundbreaking technology combines whole-organ imaging, deep-learning analysis, robotic tissue extraction, and ultra-sensitive mass spectrometry for the future of molecular analysis!

DISCO-MS matches the proteome data of uncleared samples in both rodent and human tissues. Investigate microglia activation after brain injury. Early & late-stage amyloid-beta plaques analysis in Alzheimer's disease mouse models.

DISCO-bot robotic extraction: Unveil the regional differences in immune cells in intact organisms.

Study cardiovascular and aortic plaques in unprecedented detail.

A gateway to discovering diagnostic & therapeutic opportunities for complex diseases with 3D imaging!

cFos-AI

Unleashing the power of tissue clearing and fluorescent microscopy for comprehensive protein expression studies in health and disease!

Introducing DELiVR a cutting-edge deep learning pipeline which uses virtual reality (VR) to generate training data for deep neural networks. VR annotation speeds up training data generation compared to traditional methods.

Pinpoints c-Fos, a marker for neuronal activity, in cleared mouse brains.

Achieves cellular-level resolution in mapping protein expression. Surpasses current pipelines with unparalleled precision in cell detection.

Discover unique brain activation pattern related to cancer and weight changes.

Vascular Analysis

Facing challenges with immense 3D vascular datasets? We’ve cracked the code! Introducing VesSAP: The game-changing deep learning tool for analyzing brain vasculature.

Harness the power of convolutional neural networks (CNNs) with transfer learning to achieve superb human-level accuracy.

Dive deep into the micrometer scale vascular intricacies of C57BL/6J, CD1, and BALB/c mouse brains, spinal cord and vascular graphs.

Your go-to for unbiased, scalable insights into the vascular networks of cleared mouse brains!